New method of modified chemoradiotherapy for cancer of the upper and middle ampullary rectum

The last decade is characterized by significant progress in the treatment of rectal cancer (reduction number relapses to 5–6 % with use prolonged radiation therapy) before surgery. greatest success has been achieved lower ampulla rectum, when it possible develop a complete clinical response tumor chemoradiotherapy. Nevertheless, requirement issues improve results upper and middle ampullar rectum an increase survival patients remain. Which makes relevant new methods, that effectiveness cancer. method modified chemoradiotherapy for was developed our study. as follows: at first stage, one day start therapy, patient undergoes superselective catheterization superior artery through radial or femoral artery, followed regional administration radiomodifying chemotherapy drugs: cisplatin 50 mg fluorouracil 500 mg. In day, begin undergo course conformal remote large- fraction therapy primary focus metastasis pathways 5 sessions single focal dose Gy total 25 using low-energy linear accelerator. During entire administered daily intravenously 30 minutes session. Surgical intervention sampling material research carried out 6–8 weeks after completed. To assess chemoradiotherapy, stage regression determined according RECIST scale, level therapeutic pathomorphology Dworak during morphological study removed operation. achieve short time, reduce time treatment. intended T3-4N0-2M0, whom indicated treatment, which resection performed standard volume.